5 posts
A practical comparison of mass spectrometry, affinity panels, and aptamer arrays as purchasable proteomics services, with the file formats, tools, and failure modes you should expect if you plan to analyze the data yourself.
List prices for SomaScan 7K and 11K at core facilities run $800–900 per sample before shipping, plate minimums, and analysis. Here is where that money goes, how the assay works, and how to decide between SomaScan, Olink Reveal, and a targeted panel.
A Nature Medicine study staged 80 midlife women by hormone criteria and found 16 blood proteins that track the menopause transition better than age does. What the menopause proteomic score measures, how well it replicated, and what the dementia numbers do and do not support.
A plasma proteomics report measures the relative abundance of hundreds to thousands of circulating proteins. Here is what the numbers mean, how the three main platforms differ, and how to analyze your own data without fooling yourself.
A working guide to taking personal proteomics data from raw instrument files or NPX tables to a quantitative matrix, QC'd and normalized, and then to within-person statistics you can defend.