Genomic DNA Analysis: What Your Own Genome Can Tell You, and How to Analyze It
A working guide to analyzing your own whole-genome sequence: the file formats, the pipeline we would run, and what the calls support.
Tag: privacy
10 posts
How to Work With Your Own DNA Data
A practical pipeline for taking raw DNA data — array export, VCF, or CRAM — and turning it into something you can query, annotate, and trust, plus what the file cannot tell you.
Private DNA Testing: What It Costs, What It Proves, and How to Keep the Data Yours
A technical guide to getting your DNA sequenced without handing the data to a consumer platform: what each tier of testing can resolve, where the error rates live, and how to store and analyze the files yourself.
All of Us DNA Results Are Gone. Here Is What You Can Still Get.
The All of Us Research Program stopped returning research DNA results and removed ancestry and trait reports from participant accounts. What you were given, what you never had, and how to get raw genomic data you control.
What a Confidential DNA Test Can and Cannot Guarantee
A practical guide to privacy in DNA testing: why genomes resist anonymization, what to ask a provider before you send a sample, and how to hold raw sequence data safely once you have it.
What to Do With Your DNA.Land Upload Now That the Site Is Gone
DNA.Land stopped accepting uploads and shut down its reports. This guide shows how to take the same raw genotype file, convert it to VCF, impute it, annotate it, and decide which remaining upload sites are worth your data.
The Most Private DNA Test Is One Where You Hold the Only Copy of the Data
A technical answer to what makes genetic testing private: who holds the raw files, what the consent terms permit, how re-identifiable the data is, and how to store and analyze a genome yourself.
DNA Test Privacy: What Leaks, and How to Control It
A technical account of the privacy properties of consumer and clinical DNA testing: what data exists, who holds it, what re-identification attacks work, and a concrete setup for keeping your own sequence data under your control.
Is There Such a Thing as a HIPAA-Compliant DNA Test?
HIPAA compliance is a property of the entity holding your data. No sequencing assay has it. What HIPAA covers, and how to take custody of your files.
How to Analyze Your Raw DNA Data Without a Paid Upload Site
A working guide to the free DNA upload sites worth using, what each one does with your file, and how to run the same annotation, polygenic scoring, and relative-matching analyses yourself on your own machine.