3 posts
A working pipeline for taking raw whole-genome sequencing output (FASTQ, CRAM, VCF) through quality control, annotation, and variant triage, with the specific tools, flags, and thresholds we would use and the failure modes to watch for.
Pharmacogenomic panels like myDNA and GeneSight genotype a short list of variants and return a color-coded report. Here is what those genes do, how to call the same star alleles yourself from whole-genome sequencing, and where the evidence stops.
There is no single 'Huberman blood test.' Here is the panel that gets discussed on the podcast, which markers carry real signal, and how to get the data in a form you can analyze yourself.